“Edema Macular Diabético Clínicamente Significativo: Análisis discriminante de

FORZINETTI GM; COLLINO C; BARONI MV; FERRER D; GRAMAJO AL; ESPEJO J; LUNA JD; SANCHEZ MC

Oftalmologia clinica y experimental

Consejo Argentino de Oftalmologia (CAO)

Lugar: Buenos Aires; Año: 2011

1851-2658

PURPOSE: Diabetic macular edema is a common phenomenon associated with visual loss in diabetic patients and is characterized by accumulation of extracellular fluid in the retina. Up to now, the etiopathogenesis of this disease is not well known which will be essential for the development of an effective clinical treatment. In the present work we apply discriminant analysis as statistical tools in order to associate biochemical parameters of diabetic patients with clinically significant macular edema (CSMO) from diabetic patients without CSMO. METHODS: After a complete eye examination, peripheral whole blood samples were obtained of Type II DM patients with CSME (n=9) and patients without CSME (n=21). Quantitative assays were performed for 14 different biochemical parameters measured by conventional clinical laboratory tests. All biochemical parameters were analyzed using Lineal Discriminant Analysis (forward stepwise mode) and Kruskal Wallis test. RESULTS: Discriminant analysis allows selecting 7 biochemical parameters as the most important for discrimination. These 7 parameters allow differentiating CSME patients from diabetic patients without CSME with 93,4% certainty. This means that only 2 of 30 patients analyzed were misclassified. The mean value of red cells, triglicerides, and Red Cell Distribution Width (RDW) was statistically different between groups of patients (p<0.05). CONCLUSIONS: These results indicate that these 7 biochemical parameters are key markers that highly discriminate CSME from the other patient group and could be involved in the pathogenesis of this macular pathology.