CIBICI 14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
artículos
Título:
Nitro-fatty acid formation and metabolism
Autor/es:
BONACCI, GUSTAVO; FAZZARI, MARCO; GELHAUS WENDELL, STACY; BUCHAN, GREGORY J.; SALVATORE, SONIA R.
Revista:
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Año: 2018 vol. 79 p. 38 - 44
ISSN:
1089-8603
Resumen:
Nitro-fatty acids (NO2-FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid. While we know a considerable amount regarding NO2-FA signaling, endogenous formation and metabolism is relatively unexplored. This review will cover what is currently known regarding the proposed mechanisms of NO2-FA formation, dietary modulation of endogenous NO2-FA levels, pathways of NO2-FA metabolism and the detection of NO2-FA and corresponding metabolites.
