CIBICI 14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
artículos
Título:
Diazepam treatment reduces inflammatory cells and mediators in the central nervous system of rats with experimental autoimmune encephalomyelitis
Autor/es:
BOUZAT, CECILIA; ZANETTI, SAMANTA R.; BIBOLINI, MARIO J.; FERNÁNDEZ HURST, NICOLÁS; ROTH, GERMAN A.; BÁEZ, NATALIA S.
Revista:
JOURNAL OF NEUROIMMUNOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2017
ISSN:
0165-5728
Resumen:
Benzodiazepines are psychoactive drugs and some of them also affect immune cells. We here characterized the inflammatory and infiltrating immune cells in the central nervous system (CNS) during the acute phase of experimental autoimmune encephalomyelitis (EAE) in animals treated with Diazepam. Also, we evaluated the expression of Translocator Protein (18kDa) (TSPO), which is a biomarker of neuroinflammatory diseases. The results indicate that Diazepam exerts protective effects on EAE development, decreasing the incidence of the disease and reducing the number of inflammatory cells in CNS, with a concomitant decrease of TSPO levels in brain tissue and CNS inflammatory CD11b+ cells.
