The Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Lipid Metabolism, Glucose Homeostasis and Inflammation.

CHIABRANDO, GUSTAVO A; ACTIS DATO, VIRGINA

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI

Lugar: Basel; Año: 2018

1422-0067

Metabolic syndrome (MetS) is a highly prevalent disorder which can be used to identifyindividuals with a higher risk for cardiovascular disease and type 2 diabetes. This metabolic syndromeis characterized by a combination of physiological, metabolic, and molecular alterations such asinsulin resistance, dyslipidemia, and central obesity. The low-density lipoprotein receptor-relatedprotein 1 (LRP1?A member of the LDL receptor family) is an endocytic and signaling receptorthat is expressed in several tissues. It is involved in the clearance of chylomicron remnants fromcirculation, and has been demonstrated to play a key role in the lipid metabolism at the hepaticlevel. Recent studies have shown that LRP1 is involved in insulin receptor (IR) trafficking andintracellular signaling activity, which have an impact on the regulation of glucose homeostasisin adipocytes, muscle cells, and brain. In addition, LRP1 has the potential to inhibit or sustaininflammation in macrophages, depending on its cellular expression, as well as the presence ofparticular types of ligands in the extracellular microenvironment. In this review, we summarizeexisting perspectives and the latest innovations concerning the role of tissue-specific LRP1 inlipoprotein and glucose metabolism, and examine its ability to mediate inflammatory processesrelated to MetS and atherosclerosis