CONICET | Buscador de Institutos y Recursos Humanos

Although several excellent articles have reviewed different aspects of mucosalassociated lymphoid tissues (MALT), there is not enough information about the oralcavity immune response. In this manuscript we highlight advances in the recentknowledge about this topic focusing on the anatomy/histology of the oral cavity, theassociated immunological structures and the role of dendritic cells and Tollsignalling, trying to envisage what happen when microorganisms or soluble antigensenter in the mouth. Oral mucosa has received attention in the last decade because itoffers excellent accessibility and avoids degradation of proteins and peptides.Although the oral mucosa is continuous with the remaining gastrointestinal tract,structurally the oral mucosa has more in common with skin than with thegastrointestinal tract.