CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
artículos
Título:
Oxidative stress responses in different organs of Jenynsia multidentata exposed to Endosulfan.
Autor/es:
BALLESTEROS, M.L.; WUNDERLIN, D. A.; BISTONI, M.A.
Revista:
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Editorial:
ELSEVIER
Referencias:
Lugar: USA ; Año: 2009 vol. 72 p. 199 - 205
ISSN:
0147-6513
Resumen:
We evaluate antioxidant responses of Jenynsia multidentata experimentally exposed to sublethal concentrations of endosulfan (EDS). The main goal was to determine differences in the response between different organs to assess which one was more severely affected. Thus, we exposed females of J. multidentata to EDS during 24 h, measuring the activity of GST, GR, GPx, CAT and LPO in brain, gills, liver, intestine and muscle of both exposed fish and controls. GST activity was inhibited in gills, liver, intestine and muscle of exposed fish but was induced in brain. GR and GPx activities were increased in brain and gills at 0.014 and 0.288 mgL1, respectively. GPx activity was inhibited in liver and muscle at all studied concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. liver, intestine and muscle of both exposed fish and controls. GST activity was inhibited in gills, liver, intestine and muscle of exposed fish but was induced in brain. GR and GPx activities were increased in brain and gills at 0.014 and 0.288 mgL1, respectively. GPx activity was inhibited in liver and muscle at all studied concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. liver, intestine and muscle of both exposed fish and controls. GST activity was inhibited in gills, liver, intestine and muscle of exposed fish but was induced in brain. GR and GPx activities were increased in brain and gills at 0.014 and 0.288 mgL1, respectively. GPx activity was inhibited in liver and muscle at all studied concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. liver, intestine and muscle of both exposed fish and controls. GST activity was inhibited in gills, liver, intestine and muscle of exposed fish but was induced in brain. GR and GPx activities were increased in brain and gills at 0.014 and 0.288 mgL1, respectively. GPx activity was inhibited in liver and muscle at all studied concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. The main goal was to determine differences in the response between different organs to assess which one was more severely affected. Thus, we exposed females of J. multidentata to EDS during 24 h, measuring the activity of GST, GR, GPx, CAT and LPO in brain, gills, liver, intestine and muscle of both exposed fish and controls. GST activity was inhibited in gills, liver, intestine and muscle of exposed fish but was induced in brain. GR and GPx activities were increased in brain and gills at 0.014 and 0.288 mgL1, respectively. GPx activity was inhibited in liver and muscle at all studied concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suitable bioindicator of exposure to EDS measuring activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. activities of antioxidant enzymes in brain and liver as biomarkers. concentrations whereas inhibition was observed in the intestine above 0.288 mgL1. Exposure to 1.4 mgL1 EDS caused CAT inhibition and increase of LPO levels in liver. LPO was also increased in brain at almost all concentrations tested. We find that the brain was the most sensitive organ to oxidative damage. Thus, J. multidentata could be used as a suita