Dendritic Cells and Parasites: From Recognition and Activation to Immune Response Instruction

LAURA CERVI; AMBROSIO, LF; VOLPINI, XIMENA; CELIAS, D; CLAUDIA MOTRAN

SEMINARS IN IMMUNOPATHOLOGY

SPRINGER

Lugar: Berlin; Año: 2017 vol. 39 p. 199 - 213

1863-2297

The effective defense against parasite infections requires the ability to mount an appropriate andcontrolled specific immune response able to eradicate the invading pathogen while limiting thecollateral damage to self-tissues. Dendritic cells are key elements for the development of immunityagainst parasites; they control the responses required to eliminate these pathogens while maintaininghost homeostasis. Ligation of dendritic cells Pattern Recognition Receptors by Pathogen AssociatedMolecular Pattern present in the parasites initiates signaling pathways that lead to the production ofsurface and secreted proteins that are required, together with the antigen, to induce an appropriate,and timely regulated immune response. There is evidence showing that parasites can influence andregulate dendritic cell functions in order to promote a more permissive environment for their survival.In this review, we will focus on new insights about the ability of protozoan and helminth parasites ortheir products to modify dendritic cells function and discuss how this interaction is crucial in shapingthe host response