Vulvovaginal candidiasis: an old disease with new challenges

RODRÍGUEZ E; DE FREITAS ARAUJO; ABIEGA C; VIGEZZI C; RIERA F; CAEIRO JP; MIRÓ MS; ICELY PA; VARGAS L; SOTOMAYOR CE

REVISTA IBEROAMERICANA DE MICOLOGIA

ASOCIACION ESPANOLA MICOLOGIA-AEM

Lugar: Londres; Año: 2017 vol. 33 p. 65 - 71

1130-1406

Vulvovaginal candidiasis (VVC) is an ancient disease that even in a modern world continues to present a high incidence. Despite therapeutic advances there are no effective treatments and our understanding of the pathogenesis of this fungal infection is still incomplete. This article discusses the most significant developments related to the production of fungal virulence factors, the role of immunological mechanisms involved in the vaginal protection and genetic alterations that confer susceptibility to the recurrent form of this mycosis. Current treatments, the use of new agents and development of strategies such as vaccination, are approached in the context of the complex scenario that governs the interactions between Candida and host.