CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
artículos
Título:
Control of dendritic cell maturation and function by triiodothyronine (T3)
Autor/es:
MASCANFRONI ID; MONTESINOS MM; SUSPERREGUY S; CERVI L; ILARREGUI J; RAMSEYER V; MASINI-REPISO AM; TARGOVNIK HM; RABINOVICH GA; PELLIZAS CG
Revista:
FASEB JOURNAL
Referencias:
Año: 2008 vol. 4 p. 1032 - 1042
ISSN:
0892-6638
Resumen:
Accumulating evidence indicates a functional
crosstalk between immune and endocrine mechanisms
in the modulation of innate and adaptive immunity.
However, the impact of thyroid hormones (THs)
in the initiation of adaptive immune responses has not
yet been examined. Here we investigated the presence
of thyroid hormone receptors (TRs) and the impact of
THs in the physiology of mouse dendritic cells (DCs),
specialized antigen-presenting cells with the unique
capacity to fully activate naive T cells and orchestrate
adaptive immunity. Both immature and lipopolysaccharide-
matured bone marrow-derived DCs expressed TRs
at mRNA and protein levels, showing a preferential
cytoplasmic localization. Remarkably, physiological levels
of triiodothyronine (T3) stimulated the expression
of DC maturation markers (major histocompatability
complex II, CD80, CD86, and CD40), markedly increased
the secretion of interleukin-12, and stimulated
the ability of DCs to induce naive T cell proliferation
and IFN- production in allogeneic T cell cultures.
Analysis of the mechanisms involved in these effects
revealed the ability of T3 to influence the cytoplasmicnuclear
shuttling of nuclear factor-B on primed DCs.
Our study provides the first evidence for the presence
of TRs on bone marrow-derived DCs and the ability of
THs to regulate DC maturation and function. These
results have profound implications in immunopathology,
including cancer and autoimmune manifestations
of the thyroid gland at the crossroads of the immune
and endocrine systems
Analysis of the mechanisms involved in these effects
revealed the ability of T3 to influence the cytoplasmicnuclear
shuttling of nuclear factor-B on primed DCs.
Our study provides the first evidence for the presence
of TRs on bone marrow-derived DCs and the ability of
THs to regulate DC maturation and function. These
results have profound implications in immunopathology,
including cancer and autoimmune manifestations
of the thyroid gland at the crossroads of the immune
and endocrine systems
production in allogeneic T cell cultures.
Analysis of the mechanisms involved in these effects
revealed the ability of T3 to influence the cytoplasmicnuclear
shuttling of nuclear factor-B on primed DCs.
Our study provides the first evidence for the presence
of TRs on bone marrow-derived DCs and the ability of
THs to regulate DC maturation and function. These
results have profound implications in immunopathology,
including cancer and autoimmune manifestations
of the thyroid gland at the crossroads of the immune
and endocrine systems