Recurrent vulvovaginal candisiasis: an old disease with new challenges

MIRÓ MS1 , ABIEGA C2 , ICELY PA1 , RIERA F3 , ARBACH F4 , GRUTADAURIA MG4 , VIGEZZI C1 , RODRIGUEZ E1 , CAEIRO JP5 Y CE SOTOMAYOR1 .; VIGEZZI C; ABIEGA C; ICELY PA; VARGAS L; CE SOTOMAYOR; RODRIGUEZ E; RIERA F; CAEIRO JP

REVISTA IBEROAMERICANA DE MICOLOGIA

ASOCIACION ESPANOLA MICOLOGIA-AEM

Lugar: Londres; Año: 2016

1130-1406

Vulvovaginal candidiasis is an old disease that, even in amodern world, continues to have a high incidence.Despite the therapeutic advances, treatments are not always effective, and our understanding of thepathogenesis of this fungal infection is still incomplete. A discussion is presented in this article on themost significant developments related to the fungal virulence factors, the role of the immunologicalmechanisms involved in the vaginal protection, and the genetic alterations that confer susceptibility tothe recurrent form of this mycosis. Current treatments, the use of new agents with antifungal activity, aswell as the development of strategies, such as vaccination, are approached in the context of the complexscenario that governs the interactions between Candida and its host.