CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
artículos
Título:
The regulatory role of B cells in autoimmunity, infections and cancer: Perspectives beyond IL10 production.
Autor/es:
MELISA GOROSITO SERRAN; FACUNDO FIOCCA-VERNENGO; CRISTIAN BECCARÍA; EVA V ACOSTA-RODRIGUEZ; CAROLINA MONTES; ADRIANA GRUPPI
Revista:
FEBS LETTERS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2015
ISSN:
0014-5793
Resumen:
The term regulatory B cells (B regs) is ascribed to a heterogeneous population of B cells with the function of suppressing inflammatory responses. They have been described mainly during the last decade in the context of different immune-mediated diseases. Most of the work on B regs has been focused on IL-10-producing B cells. However, B cells can exert regulatory functions independently of IL-10 production. Here we discuss the phenotypes, development and effector mechanisms of B regs and advances in their role in autoimmunity, infections and cancer.