Early effects triggered by Larrea divaricata on murine macrophages at apoptotic concentrations.

DAVICINO, ROBERTO; MATTAR, AIDA; CASALI, YOLANDA; PORPORATTO CARINA; CORREA, SILVIA G; MICALIZZI, BLAS

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Francis & Taylor Group

Año: 2007 vol. 29 p. 611 - 624

0892-3973

Decoction and infusion of Larrea divaricata were tested at apoptotic concentrations (1 and 4 mg/ml) on peritoneal murine macrophages. Consistent changes were observed after incubation with 4 mg/ml decoction. Phagocytosis of zymosan, lysosomal enzyme activity, nitric oxide production, TNF-alpha release, and expression of CD14, TLR4, and CR3 increased significantly. Decoction at 1 and 4 mg/ml increased the binding of LPS-FITC. Apoptosis triggered by L divaricata decoction is consequence of cell activation. The effects are independent of nordihydroguaiaretic acid. This activation and death could be the mechanism of L. divaricata to exert the antituberculosis effect known in folk medicine.