CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
artículos
Título:
The Role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in Regulating the Innate and Adaptive Immune Response.
Autor/es:
MARTINEZ FF; . CERVI L.; KNUBEL C; PANZETTA-DUTARI G; MOTRAN C.C.
Revista:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Lugar: Londres; Año: 2013 vol. 69 p. 383 - 394
ISSN:
1046-7408
Resumen:
Among several explanations for the acceptance of the fetus, the one that
suggests that the maternal immune system is suppressed or modified
has been the subject of many studies. Thus, it has been proposed that
the cells of innate immune system might be able to distinguish the pregnant
from the non-pregnant state producing a signal, the so-called
signal P. We have previously proposed that pregnancy-specific glycoprotein
1a (PSG1a), a representative member of the main glycoprotein family
secreted by placental trophoblast, may modulate the activation of
antigen-presenting cells promoting the T-cell shift of the maternal cell
immunity toward a less harmful phenotype. In this review, we summarize
current knowledge concerning the contribution of pregnancyspecific
glycoprotein 1a (PSG1a) to modulate the maternal innate and
adaptive immune response in order to assure a successful pregnancy