CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
artículos
Título:
The Lipid Transfer Protein StarD7: Structure, Function, and Regulation
Autor/es:
FLORES-MARTÍN JÉSICA; RENA VIVIANA; ANGELETTI SOFÍA; PANZETTA DE DUTARI GRACIELA; GENTI DE RAIMONDI SUSANA
Revista:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Editorial:
MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
Referencias:
Lugar: Basel; Año: 2013 vol. 14 p. 6170 - 6186
ISSN:
1422-0067
Resumen:
Abstract: The steroidogenic acute regulatory (StAR) protein-related lipid transfer (START)domain proteins constitute a family of evolutionarily conserved and widely expressed proteins that have been implicated in lipid transport, metabolism, and signaling. The 15 well-characterized mammalian START domain-containing proteins are grouped into six subfamilies. The START domain containing 7 mRNA encodes StarD7, a member of the StarD2/phosphatidylcholine transfer protein (PCTP) subfamily, which was first identified as a gene overexpressed in a choriocarcinoma cell line. Recent studies show that the StarD7 protein facilitates the delivery of phosphatidylcholine to the mitochondria. This review summarizes the latest advances in StarD7 research, focusing on the structural and biochemical features, protein-lipid interactions, and mechanisms that regulate StarD7 expression. The implications of the role of StarD7 in cell proliferation, migration, and differentiation are also discussed.