CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
artículos
Título:
Non-immune cells contribute to cross-talk between immune cells and inflammatory mediators in the innate response to Trypanosoma cruzi infection
Autor/es:
AOKI, MARIA DEL PILAR; CARRERA SILVA, ANTONIO; CUERVO, HENAR; FRESNO, MANUEL; GIRONÉS, NURIA; GEA, SUSANA
Revista:
Journal of Parasitology Research
Editorial:
Hindawi Publishing Corporation
Referencias:
Año: 2012 vol. 2012 p. 1 - 13
ISSN:
2090-0031
Resumen:
Chagas myocarditis, which is caused by infection with the intracellular parasite Trypanosoma cruzi, remains the major infectious
heart disease worldwide. Innate recognition through toll-like receptors (TLRs) on immune cells has not only been revealed to
be critical for defense against T. cruzi but has also been involved in triggering the pathology. Subsequent studies revealed that this
parasite activates nucleotide-binding oligomerization domain- (NOD-)like receptors and several particular transcription factors in
TLR-independent manner. In addition to professional immune cells, T. cruzi infects and resides in different parenchyma cells. The
innate receptors in nonimmune target tissues could also have an impact on host response. Thus, the outcome of themyocarditis or
the inflamed liver relies on an intricate network of inflammatory mediators and signals given by immune and nonimmune cells.
In this paper, we discuss the evidence of innate immunity to the parasite developed by the host, with emphasis on the crosstalk
between immune and nonimmune cell responses.