CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
artículos
Título:
Gut Epithelial Lining Makes the First Move
Autor/es:
CANALI M, PORPORATTO C, CORREA SG.
Revista:
Current Immunology Reviews
Editorial:
Benthan Science Publishers
Referencias:
Año: 2011 vol. 3 p. 264 - 270
ISSN:
1573-3955
Resumen:
Abstract
The mucosal immune system is ruled by a distinctive set of mechanisms
derived of the local microenvironment demands. Intestinal epithelial cells (IECs)
represent a unique population of cells that exist in direct contact with a burden
of bacteria and provide a primary physical barrier between the antigenic
overload of the lumen and leukocytes settled in the lamina propria. The cross
talk between these compartments maintains the intestinal homeostasis.
The network of dendritic cells (DCs) in the vicinity of IECs is crucial in this
process as DC maturation across the epithelial barrier seems to be dependent
on the presence of specific surface factors. IECs are broadly unresponsive to
gram-positive bacterial components, notably TLR-2 ligands, in contrast to gramnegative
bacterial components. The TLR signaling is tightly regulated in IECs to
avoid uncontrolled inflammation by several negative regulators that include IAP,
A20, NOD2, and IRAK-M