CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
artículos
Título:
Toll-like receptors and diseases
Autor/es:
IRIBARREN P; WANG JM
Revista:
INTERNATIONAL IMMUNOPHARMACOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2011 p. 1389 - 1390
ISSN:
1567-5769
Resumen:
Despite the progress achieved in recently years, studies of TLRs in
diseases still face challenges. Many fundamental questions concerning
the precise role of each TLR in a particular disease remain to be
elucidated. This calls for more rigorous testing with in vivo models
using animal deficient in one or more TLRs, and in some more mature
circumstances, agonists or antagonists of TLRs with clear molecular
mechanisms and under strict ethical regulation need to be tested
directly on human diseases. It is conceivable that with time new
questions may arise but we have every reason to be optimistic that rapid
growth in our knowledge of TLRs should result in major breakthrough in
the development of therapeutic agents for human diseases.