CIBICI   14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
artículos
Título:
Male genital tract infection with Chlamydia muridarum: special tropism for the prostate gland and its pathogenic consequences
Autor/es:
JUAN PABLO MACKERN-OBERTI; RUBEN DARIO MOTRICH; MARIA LAURA BRESER; HUGO CEJAS; CECILIA CUFFINI; MARIANA MACCIONI; VIRGINIA RIVERO
Revista:
JOURNAL OF UROLOGY
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Año: 2011 vol. 186 p. 1100 - 1106
ISSN:
0022-5347
Resumen:
Purpose: We investigated Chlamydia trachomatis infection and its pathogenic
consequences in the male rodent genital tract.
consequences in the male rodent genital tract.
We investigated Chlamydia trachomatis infection and its pathogenic
consequences in the male rodent genital tract.
Materials and Methods: Male rats were inoculated in the meatal urethra with
Chlamydia muridarum. We sought bacterial DNA at early and late times after
inoculation in different parts of the male genital tract. Histological alterations
and the immune response against prostate antigens were analyzed.
Chlamydia muridarum. We sought bacterial DNA at early and late times after
inoculation in different parts of the male genital tract. Histological alterations
and the immune response against prostate antigens were analyzed.
Male rats were inoculated in the meatal urethra with
Chlamydia muridarum. We sought bacterial DNA at early and late times after
inoculation in different parts of the male genital tract. Histological alterations
and the immune response against prostate antigens were analyzed.
Results: Male rats showed ascending infection with wide dissemination of bacteria
in the genital tract at an early time point after inoculation. At later stages
bacteria persisted only in some parts of the genital tract and in the prostate
gland. C. muridarum was also detected in semen in a high proportion of rats
irrespective of an acute or chronic stage of infection. Histological alterations that
accompanied C. muridarum were especially observed in the prostate and mainly
composed of CD3 cell infiltration. Positive humoral and cellular responses
against prostate antigens were noted in a considerable number of infected rats.
NOD mice, an autoimmune, prostatitis prone strain, showed a similar pattern
with C. muridarum in the prostate of 100% of infected mice, which was again
accompanied by mononuclear cell infiltration and antibodies against prostate
antigens at early and late times after inoculation.
against prostate antigens were noted in a considerable number of infected rats.
NOD mice, an autoimmune, prostatitis prone strain, showed a similar pattern
with C. muridarum in the prostate of 100% of infected mice, which was again
accompanied by mononuclear cell infiltration and antibodies against prostate
antigens at early and late times after inoculation.
in the genital tract at an early time point after inoculation. At later stages
bacteria persisted only in some parts of the genital tract and in the prostate
gland. C. muridarum was also detected in semen in a high proportion of rats
irrespective of an acute or chronic stage of infection. Histological alterations that
accompanied C. muridarum were especially observed in the prostate and mainly
composed of CD3 cell infiltration. Positive humoral and cellular responses
against prostate antigens were noted in a considerable number of infected rats.
NOD mice, an autoimmune, prostatitis prone strain, showed a similar pattern
with C. muridarum in the prostate of 100% of infected mice, which was again
accompanied by mononuclear cell infiltration and antibodies against prostate
antigens at early and late times after inoculation.
against prostate antigens were noted in a considerable number of infected rats.
NOD mice, an autoimmune, prostatitis prone strain, showed a similar pattern
with C. muridarum in the prostate of 100% of infected mice, which was again
accompanied by mononuclear cell infiltration and antibodies against prostate
antigens at early and late times after inoculation.
Male rats showed ascending infection with wide dissemination of bacteria
in the genital tract at an early time point after inoculation. At later stages
bacteria persisted only in some parts of the genital tract and in the prostate
gland. C. muridarum was also detected in semen in a high proportion of rats
irrespective of an acute or chronic stage of infection. Histological alterations that
accompanied C. muridarum were especially observed in the prostate and mainly
composed of CD3 cell infiltration. Positive humoral and cellular responses
against prostate antigens were noted in a considerable number of infected rats.
NOD mice, an autoimmune, prostatitis prone strain, showed a similar pattern
with C. muridarum in the prostate of 100% of infected mice, which was again
accompanied by mononuclear cell infiltration and antibodies against prostate
antigens at early and late times after inoculation.
against prostate antigens were noted in a considerable number of infected rats.
NOD mice, an autoimmune, prostatitis prone strain, showed a similar pattern
with C. muridarum in the prostate of 100% of infected mice, which was again
accompanied by mononuclear cell infiltration and antibodies against prostate
antigens at early and late times after inoculation.
cell infiltration. Positive humoral and cellular responses
against prostate antigens were noted in a considerable number of infected rats.
NOD mice, an autoimmune, prostatitis prone strain, showed a similar pattern
with C. muridarum in the prostate of 100% of infected mice, which was again
accompanied by mononuclear cell infiltration and antibodies against prostate
antigens at early and late times after inoculation.
Conclusions: Results reveal that C. muridarum infects the male rodent genitourinary
tract with special persistence in the prostate gland, where it causes
chronic inflammation that in turn may act as a trigger factor for self-immune
reactions in susceptible hosts
tract with special persistence in the prostate gland, where it causes
chronic inflammation that in turn may act as a trigger factor for self-immune
reactions in susceptible hosts
Results reveal that C. muridarum infects the male rodent genitourinary
tract with special persistence in the prostate gland, where it causes
chronic inflammation that in turn may act as a trigger factor for self-immune
reactions in susceptible hosts