In vitro immunomodulatory effects of fractons obtained from acqueous extracts of Larrea divaricata Cav (jarilla) on mouse peritoneal macrophages.

MARTINO RF, DAVICINO RC, MATTAR MA, CASALI YA, CORREA SG, ANESINI C, MICALIZZI B.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Francis & Taylor Group

Año: 2010 p. 125 - 132

0892-3973

Larrea divaricata Cav. (Zygophyllaceae) is a plant widely used in Argentinean. Herein we isolated different fractions of L. divaricata aqueous extract containing minor amounts of NDGA and we analyzed these fractions on mouse macrophages. We showed that a fraction without NDGA was capable to activate macrophages, principally through the production of mitochondrial anion superoxide and H2O2. This could be important in the defense of infections. Moreover, this fraction decreased NO level suggesting an antiinflammatory action. These results indicate that NDGA was not the compound responsible of the immunomodulatory action exerts by the aqueous extract from L. divaricata. divaricata. the defense of infections. Moreover, this fraction decreased NO level suggesting an antiinflammatory action. These results indicate that NDGA was not the compound responsible of the immunomodulatory action exerts by the aqueous extract from L. divaricata. divaricata. amounts of NDGA and we analyzed these fractions on mouse macrophages. We showed that a fraction without NDGA was capable to activate macrophages, principally through the production of mitochondrial anion superoxide and H2O2. This could be important in the defense of infections. Moreover, this fraction decreased NO level suggesting an antiinflammatory action. These results indicate that NDGA was not the compound responsible of the immunomodulatory action exerts by the aqueous extract from L. divaricata. divaricata. the defense of infections. Moreover, this fraction decreased NO level suggesting an antiinflammatory action. These results indicate that NDGA was not the compound responsible of the immunomodulatory action exerts by the aqueous extract from L. divaricata. divaricata. we isolated different fractions of L. divaricata aqueous extract containing minor amounts of NDGA and we analyzed these fractions on mouse macrophages. We showed that a fraction without NDGA was capable to activate macrophages, principally through the production of mitochondrial anion superoxide and H2O2. This could be important in the defense of infections. Moreover, this fraction decreased NO level suggesting an antiinflammatory action. These results indicate that NDGA was not the compound responsible of the immunomodulatory action exerts by the aqueous extract from L. divaricata. divaricata. the defense of infections. Moreover, this fraction decreased NO level suggesting an antiinflammatory action. These results indicate that NDGA was not the compound responsible of the immunomodulatory action exerts by the aqueous extract from L. divaricata. divaricata. amounts of NDGA and we analyzed these fractions on mouse macrophages. We showed that a fraction without NDGA was capable to activate macrophages, principally through the production of mitochondrial anion superoxide and H2O2. This could be important in the defense of infections. Moreover, this fraction decreased NO level suggesting an antiinflammatory action. These results indicate that NDGA was not the compound responsible of the immunomodulatory action exerts by the aqueous extract from L. divaricata. divaricata. the defense of infections. Moreover, this fraction decreased NO level suggesting an antiinflammatory action. These results indicate that NDGA was not the compound responsible of the immunomodulatory action exerts by the aqueous extract from L. divaricata. divaricata. (Zygophyllaceae) is a plant widely used in Argentinean. Herein we isolated different fractions of L. divaricata aqueous extract containing minor amounts of NDGA and we analyzed these fractions on mouse macrophages. We showed that a fraction without NDGA was capable to activate macrophages, principally through the production of mitochondrial anion superoxide and H2O2. This could be important in the defense of infections. Moreover, this fraction decreased NO level suggesting an antiinflammatory action. These results indicate that NDGA was not the compound responsible of the immunomodulatory action exerts by the aqueous extract from L. divaricata. divaricata. the defense of infections. Moreover, this fraction decreased NO level suggesting an antiinflammatory action. These results indicate that NDGA was not the compound responsible of the immunomodulatory action exerts by the aqueous extract from L. divaricata. divaricata. amounts of NDGA and we analyzed these fractions on mouse macrophages. We showed that a fraction without NDGA was capable to activate macrophages, principally through the production of mitochondrial anion superoxide and H2O2. This could be important in the defense of infections. Moreover, this fraction decreased NO level suggesting an antiinflammatory action. These results indicate that NDGA was not the compound responsible of the immunomodulatory action exerts by the aqueous extract from L. divaricata. divaricata. the defense of infections. Moreover, this fraction decreased NO level suggesting an antiinflammatory action. These results indicate that NDGA was not the compound responsible of the immunomodulatory action exerts by the aqueous extract from L. divaricata. divaricata. L. divaricata aqueous extract containing minor amounts of NDGA and we analyzed these fractions on mouse macrophages. We showed that a fraction without NDGA was capable to activate macrophages, principally through the production of mitochondrial anion superoxide and H2O2. This could be important in the defense of infections. Moreover, this fraction decreased NO level suggesting an antiinflammatory action. These results indicate that NDGA was not the compound responsible of the immunomodulatory action exerts by the aqueous extract from L. divaricata. divaricata. the defense of infections. Moreover, this fraction decreased NO level suggesting an antiinflammatory action. These results indicate that NDGA was not the compound responsible of the immunomodulatory action exerts by the aqueous extract from L. divaricata. divaricata. 2O2. This could be important in the defense of infections. Moreover, this fraction decreased NO level suggesting an antiinflammatory action. These results indicate that NDGA was not the compound responsible of the immunomodulatory action exerts by the aqueous extract from L. divaricata. divaricata. L. divaricata..