CIBICI 14215
CENTRO DE INVESTIGACION EN BIOQUIMICA CLINICA E INMUNOLOGIA
Unidad Ejecutora - UE
artículos
Título:
Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve
Autor/es:
CAFARO T A,; SANTOS S; ROBLES L,; CRIM N; URRETS-ZAVALIA JA; SERRA H M
Revista:
MOLECULAR VISION
Editorial:
MOLECULAR VISION
Referencias:
Año: 2010 vol. 16 p. 1654 - 1658
ISSN:
1090-0535
Resumen:
Purpose: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadavereyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls.Methods: Western analysis, ELISA, and immunohistochemical analysis were performed with human tissues.Results: We report over expression of PAD2 and higher levels of its product protein-bound citrulline in the optic nerveof normal tension glaucoma patients (NTG).Conclusions: This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2and protein-bound citrulline.
