IBR   13079
INSTITUTO DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Mechanism, evolution and inhibition of Zn(II)-dependent lactamases: a new global threat
Autor/es:
A. J. VILA
Lugar:
Chascomús
Reunión:
Encuentro; IV Latin American Meeting on Biological Inorganic Chemistry - V WOQUIBIO; 2014
Resumen:
10.2217/FMB.13.34 © 2013 Future Medicine Ltd
ISSN 1746-0913
Future Microbiol.
(2013)
8
(8), 947?949
Future Microbiology
part of
947
Zn(II) is an essential metal ion in living
organisms, playing a wide variety of roles as a
structural, regulatory or catalytic cofactor in
proteins, that is able to interact with approxi
-
mately 10% of the entire proteome in humans
[1]
. As is the case for most transition metal ions,
high Zn(II) levels are toxic. Therefore, organ
-
isms have developed a series of mechanisms to
regulate Zn(II) concentrations and to ensure
proper metal uptake by metalloproteins
[2]
.
These mechanisms involve specific metal sensor
proteins, import and export machineries that
allow subcellular compartmentalization and a
pool of small molecules and/or proteins that are
able to bind excess Zn(II)
[2]
. As a result, there
is rarely free Zn(II) within cells and biological flu