IBR 13079
INSTITUTO DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Recombinant approaches to large polyketide molecules as potential drugs
Autor/es:
PEIRÚ, S; GRAMAJO, H; MENZELLA, H
Revista:
Drug Discovery Today: Technologies
Editorial:
ELSEVIER
Referencias:
Lugar: Amsterdam; Año: 2010 vol. 7 p. 105 - 113
ISSN:
1740-6749
Resumen:
Combinatorial biosynthesis of polyketide synthases through genetic engineering may provide complex compounds as drug development candidates. Different strategies are currently being evaluated to create libraries of new compounds. The number of different compounds in such libraries and the quantities that can be made using combinatorial strategies will determine the impact of this technology on the pharmaceutical industry
