Distinct mechanisms of dissemination of NDM-1 metallo-β-lactamase in acinetobacter species in Argentina

TRAGLIA, G.M.; PASTERAN, F; LIU, CHRISTINE; GONZALEZ, LISANDRO J.; HUANG, F.; A.J. VILA; LOPEZ, CAROLINA; CORSO, ALEJANDRA; RAMIREZ, MARIA SOLEDAD; M.D. ADAMS; MARTINEZ, JASMINE; FERNANDEZ, JENNIFER S.; ALBORNOZ, E; BONOMO, ROBERT A.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

American Society for MicrobiologyJournals@asmusa.org

Lugar: Washington DC; Año: 2020 vol. 64 p. 1 - 6

0066-4804

A 4-year surveillance of carbapenem-resistant Acinetobacter spp. isolates in Argentina identified 40 strains carrying blaNDM-1. Genome sequencing revealed that most were Acinetobacter baumannii, whereas seven represented other Acinetobacter spp. The A. baumannii genomes were closely related, suggesting recent spread. blaNDM-1 was located in the chromosome of A. baumannii strains and on a plasmid in non-A. baumannii strains. A resistance gene island carrying blaPER-7 and other resistance determinants was found on a plasmid in some A. baumannii strains.