IBR 13079
INSTITUTO DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Evidence of Association between Epstein Barr Virus Serum Antibodies with HAs and RI as Biomarkers of Active Rheumatoid Arthritis
Autor/es:
URLI, LEDA; GARDIOL, DANIELA; PEREZ, GERMAN; VOLPINTESTA, RICARDO; SVETAZ, MARIA JOSE; GIRI, ADRIANA; TABORDA, MIGUEL ANGEL; LUQUITA, ALEJANDRA; URLI, LEDA; GARDIOL, DANIELA; PEREZ, GERMAN; VOLPINTESTA, RICARDO; GIRI, ADRIANA; SVETAZ, MARIA JOSE; TABORDA, MIGUEL ANGEL; LUQUITA, ALEJANDRA
Revista:
Current Biomarkers
Editorial:
Bentham Science.
Referencias:
Año: 2018 vol. 7 p. 41 - 46
ISSN:
2468-4228
Resumen:
Background: Epstein Barr Virus (EBV) infection has been associated with the Rheumatoid Arthritis (RA) etiopathology, thus, considering it a relevant etiological agent in the disease develop- ment. We have previously observed the hyaluronic acid (HA) serum increase in active RA patients (DAS 28-4 > 2.6) which might be responsible for the erythrocyte deformability, estimated by the erythrocyte rigidity index (RI).Objective: In the present study, we analyzed in one hundred RA patients if anti-EBV serum antibodies (TsEBV) and HA and RI levels are related with the disease activity. Results: [HA] s [[controls]]: 20.0 ± 9; [HA] s [[AR]]: 155.8 ± 44 (p< 0.00001 vs. controls (n:40). Antibodies anti-EBV (1/ TsEBV) [[controls]]: 2.55 ± 0.49; [[RA]]: 1.85 ± 0.35 (p< 0.00001 vs. controls). There were significant corre- lations between DAS 28-4 vs. log2 1/TsEBV (r: 0.70, p < 0.00001) and DAS 28-4 vs. RI (r: 0.75, p < 0.00001) in active RA patients. However, we observed a strong positive correlation between [HA] s in active RA patients vs. log2 1/TsEBV (r: 0.83, p < 0.00001) and [HA] s vs. RI (r: 0.91, p < 0.00001). Conclusion: The correlation obtained points out that the TsEBV may be related with the degree of RA activity determined by DAS28-4 and [HA]s in these patients. There was also a decrease in eryth- rocyte deformability estimated as RI, which is correlated with the DAS 28-4 activity index. Therefore, RI can be used as a reliable marker of RA activity. These findings might suggest a role of EBV infec- tion regarding an autoimmune mechanism present in RA.
