IBR   13079
INSTITUTO DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators
Autor/es:
MCEWAN, IAIN J.; GARCÍA, JESÚS; HUNTER, IRENE; FENWICK, R. BRYN; DI SANZA, CLAUDIO; SALVATELLA, XAVIER; ESTÉBANEZ-PERPIÑÁ, EVA; BRUN-HEATH, ISABELLE; MASÍN, MARIANELA; SALVATELLA, XAVIER; BERTONCINI, CARLOS W.; ESTÉBANEZ-PERPIÑÁ, EVA; SZULC, ELZBIETA; BRUN-HEATH, ISABELLE; MASÍN, MARIANELA; BERTONCINI, CARLOS W.; SZULC, ELZBIETA; NEBREDA, ÁNGEL R.; DE FABRITIIS, GIANNI; BUZÓN, VÍCTOR; FRIGOLÉ-VIVAS, MARTA; MARTÍNEZ-CRISTÓBAL, PAULA; DE MOL, EVA; NEBREDA, ÁNGEL R.; DE FABRITIIS, GIANNI; BUZÓN, VÍCTOR; FRIGOLÉ-VIVAS, MARTA; MARTÍNEZ-CRISTÓBAL, PAULA; DE MOL, EVA; MCEWAN, IAIN J.; GARCÍA, JESÚS; HUNTER, IRENE; FENWICK, R. BRYN; DI SANZA, CLAUDIO
Revista:
STRUCTURE WITH FOLDING & DESIGN.
Editorial:
CELL PRESS
Referencias:
Lugar: United States; Año: 2017 vol. 26 p. 145 - 152
ISSN:
0969-2126
Resumen:
The androgen receptor is a transcription factor that plays a key role in the development of prostate cancer, and its interactions with general transcription regulators are therefore of potential therapeutic interest. The mechanistic basis of these interactions is poorly understood due to the intrinsically disordered nature of the transactivation domain of the androgen receptor and the generally transient nature of the protein-protein interactions that trigger transcription. Here, we identify a motif of the transactivation domain that contributes to transcriptional activity by recruiting the C-terminal domain of subunit 1 of the general transcription regulator TFIIF. These findings provide molecular insights into the regulation of androgen receptor function and suggest strategies for treating castration-resistant prostate cancer.