IBR 13079
INSTITUTO DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain
Autor/es:
MARCHIARO P; TOMATIS PE; MUSSI MA; PASTERAN F; VIALE AM; LIMANSKY AS; VILA AJ
Revista:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Editorial:
ASM Press
Referencias:
Año: 2008 vol. 52 p. 2250 - 2252
ISSN:
0066-4804
Resumen:
A detailed biochemical characterization of the Pseudomonas aeruginosa VIM-11 metallo-beta-lactamase (MBL) is reported. The only substitution differentiating VIM-11 from VIM-2 (N165S) promoted a slightly improved catalytic efficiency of the former on 3 out of 12 substrates, notably the bulky cephalosporins. Thus, MBLmediated resistance also may be modulated by remote mutations.
