IBR   13079
INSTITUTO DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles
Autor/es:
TEKWANI, BABU L.; LABADIE, GUILLERMO R.; SERRA, ESTEBAN C.; NOCITO, ISABEL; LEPESHEVA, GALINA I.; JÄGER, SEBASTIÁN N.; PORTA, EXEQUIEL O. J.
Revista:
Med. Chem. Commun.
Editorial:
Royal Chemical Sociery
Referencias:
Lugar: Londres; Año: 2017 vol. 8 p. 1015 - 1021
ISSN:
2040-2503
Resumen:
A series of prenyl 1,2,3-triazoles were prepared from isoprenyl azides and different alkynes. The dipolar cycloaddition reaction provided exclusively primary azide products as regioisomeric mixtures that were separated by column chromatography and then fully characterized. Most of the compounds displayed antiparasitic activity against Trypanosoma cruzi and Leishmania donovani. The most active compounds were assayed as potential TcCYP51 inhibitors.