IBR   13079
INSTITUTO DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Regulation of magnesium homeostasis in Salmonella: Mg2+ targets the mgtA transcript for degradation by RNase E
Autor/es:
SPINELLI, S. V.; PONTEL, L.. B.; GARCÍA VÉSCOVI, E.; SONCINI, F. C.
Revista:
FEMS MICROBIOLOGY LETTERS
Editorial:
Blackwell Publishing Ltd.
Referencias:
Año: 2008 vol. 280 p. 226 - 234
ISSN:
0378-1097
Resumen:
Extracellular Mg(2+) controls the activation of the Salmonella PhoP/PhoQ regulatory system. One of the adaptive responses driven by PhoP/PhoQ includes the transcriptional induction of mgtA and mgtCB, which encode two P-type Mg(2+) transporters. Mg(2+) also controls mgtA expression by a riboswitch located in its 5´-untranslated region (5´UTR). In this work, it was shown that the 5´UTR of both mgtA and mgtCB is responsible for a fine-tuned Mg(2+)-dependent regulation of these genes. Evidence was also provided that the Mg(2+) riboswitch targets the mgtA transcript for degradation by RNase E when cells are grown in high Mg(2+) environments