IBR   13079
INSTITUTO DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Thermosensing via transmembrane protein-lipid interactions
Autor/es:
SAITA M; DE MENDOZA, D.
Revista:
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 1848 p. 1757 - 1764
ISSN:
0005-2736
Resumen:
Cell membranes are composed of a lipid bilayer containing proteins that cross and/or interact with lipids oneither side of the two leaflets. The basic structure of cell membranes is this bilayer, composed of two opposinglipidmonolayerswith fascinating properties designed to performall the functions the cell requires. To coordinatethese functions, lipid composition of cellularmembranes is tailored to suit their specialized tasks. In this review,we describe the general mechanisms of membrane?protein interactions and relate them to some of the molecularstrategies organisms use to adjust the membrane lipid composition in response to a decrease in environmentaltemperature. While the activities of all biomolecules are altered as a function of temperature, thethermosensors we focus on here are molecules whose temperature sensitivity appears to be linked to changesin the biophysical properties of membrane lipids. This article is part of a Special Issue entitled: Lipid?proteininteractions.