IBR   13079
INSTITUTO DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules
Autor/es:
BOUDREAU, M.A.; FISHOVITZ, J.; LLARRULL, L.I.; XIAO, Q.; MOBASHERY, S.*
Revista:
ACS Infectious Diseases
Editorial:
ACS Publications
Referencias:
Lugar: Washington DC, USA; Año: 2015 vol. 1 p. 454 - 459
ISSN:
2373-8227
Resumen:
Methicillin-resistant Staphylococcus aureus (MRSA), an important human pathogen, has evolved an inducible mechanism for resistance to beta-lactam antibiotics. We report herein that the integral membrane protein BlaR1, the beta-lactam sensor/signal transducer protein, is phosphorylated on exposure to beta-lactam antibiotics. This event is critical to the onset of the induction of antibiotic resistance. Furthermore, we document that BlaR1 phosphorylation and the antibiotic resistancephenotype are both reversed in the presence of synthetic protein kinase inhibitors of our design, restoring susceptibility of the organism to a penicillin, resurrecting it from obsolescence in treatment of these intransigent bacteria