Zn-doped Magnetite nanoparticles for hyperthermia treatment

P. MENDOZA ZÉLIS; G. PASQUEVICH; B. PIANCIOLA; M. FERNÁNDEZ VAN RAAP; S. J. STEWART; J. APHESTEGUY; A. FOSSATI; S. JACOBO; F. H. SÁNCHEZ

Campinas

Encuentro; Reunión Anual Usuarios de LNLS; 2011

Laboratorio Nacional de Luz Sincrotrón

It has been demonstrated that ferrofluids can be used for localized hyperthermia treatment due to magnetic relaxation heating effects in the presence of a radiofrequency (RF) magnetic field. Magnetic nanoparticles (MNP) relaxation can increase tumor temperature above 43ºC and selectively kill tumor cells. One important feature of MNP for hyperthermia therapy is their specific loss power (SLP), which determines the heating rate during treatments.I n this work ZnxFe(3-x)O4 (0 ≤ x ≤ 0.5) MNP and aqueous ferrofluids were prepared.Mean sizes (> 40 nm) and compositions were envisaged to produce high SLP. To this end, Zn concentration was varied to optimize the saturation magnetization Ms. Materials were characterized with several techniques to determine their structural, microstructural and magnetic properties and correlate them with their SLP performance.