Peripheral nerve regeneration: potential application of adipose-derived stem cells(AdSC) and magnetic nanoparticles.

P. A. SOTO; G. PIÑERO; V. USACH; D. F. CORAL; P. SETTON-AVRUJ; M. B. FERNÁNDEZ VAN RAAP

Polo Científico y Tecnológico, Buenos Aires

Workshop; Workshop The role of glial cells in health and disease of the Nervous System: Clinical and Basic Science walking together, 2nd Latin-American School on glial cells in the diseased brain; 2017

Neuropathies are common problems in public health, comparable in prevalence with stroke. Peripheral nervous system (PNS) injuries have a high incidence worldwide and, despite the greatregenerative capability of the PNS compared to that of the central nervous system, the poor clinical evolution of patients turns PNS affection into a crippling condition, which is why the development ofnew regenerative therapies is of great importance in treatment.Wallerian degeneration (WD) is an efficient experimental animal model in mimicking the impact of peripheral nerve lesion and shedding light on possible regeneration strategies. Research in stem cellshas recently become an important tool to accelerate regeneration in the PNS and finally achieve full functional recovery of injured nerves. Mesenchymal stem cells (MSCs) are adult stem cells thatpossess self-renewal and multi-lineage differentiation potential and are considered an attractive source of stem cells for tissue engineering.Adipose-derived stem cell (AdSC) transplant is a promising tool for regenerative therapies. They can be easily obtained through non-invasive methods, render high cell yields, proliferate easily,differentiate into many cell types and, most relevant, they can be used safely in autologous and heterologous transplant due to low immunogenicity. By endocytosis, AdSC in culture can internalize ironoxide magnetic nanoparticles (MNP), which can be driven to the lesion site by an external permanent static magnetic field applied on the rat ipsilateral limb.