INSTITUTO DE FISICA LA PLATA
Unidad Ejecutora - UE
congresos y reuniones científicas
Remote drug release study using ferrogels under AC fields
I J BRUVERA; HERNÁNDEZ R; GERARDO F. GOYA; MIJANGOS C
Workshop; Latin American Workshop on Magnetism, Magnetic Materials and their Applications; 2013
A dedicated device was built with the purpose of studying the remotely controlled drug release of a temperature sensitive hydrogel in a water flow. Hydrogels (semi-interpenetrating polymer networks constituted by alginate and PNIPAAm) with in situ synthesized magnetite nanoparticles (average size 10 nm) were characterised by TEM, STEM/EDS, SEM, VSM and power dissipation measurements. These results were used to design and construct a system able to measure drug release in a water flow when exposing the hydrogel to an external RF field. The device was calibrated to obtain absolute values of drug concentration in real time by a built-in photometer. Vitamin B12 was used as model of drug. Preliminary results indicate a good response of both the sample and the device. Field induced drug release recording show a released B12 mass in the order of 10 ng for each event. Further experiments are necessary for a complete characterization of the drug release process.