IFLP 13074
INSTITUTO DE FISICA LA PLATA
Unidad Ejecutora - UE
artículos
Título:
Synthesis, molecular structure and physicochemical properties of bis(3´-azido-3´-deoxythymidin-5-yl) carbonate
Autor/es:
M. A. RAVIOLO; P. A. M. WILLIAMS; S. B. ETCHEVERRY; O. E. PIRO; E. E. CASTELLANO; M. S. GUALDESIA; M. C. BRIÑÓN
Revista:
JOURNAL OF MOLECULAR STRUCTURE
Editorial:
Elsevier
Referencias:
Año: 2010 vol. 970 p. 59 - 65
ISSN:
0022-2860
Resumen:
3-Azido-3-deoxythymidine (zidovudine, AZT), a synthetic analog of natural nucleoside thymidine, has been used extensively in AIDS treatments. We report here the synthesis, X-ray crystal and molecular structure, NMR, IR and Raman spectra and the thermal behavior of a novel carbonate of AZT [(AZT-O)2C=O], prepared by the reaction of zidovudine with carbonyldiimidazole. The carbonate compound, C21H24N10O9, crystallizes in the tetragonal space group P41212 with a=b=15.284(1), c=21.695(1) Å, and Z=8 molecules per unit cell. It consists of two AZT moieties of closely related conformations which are bridged by a carbonyl group to adopt a folded Z-like shape.
