Structural and spectroscopic characterization of 2,2’-methylenedi-8-quinolinol dihydrochloride dihydrate

J. ZINCZUK; O. E. PIRO; E. E. CASTELLANO; E. J. BARAN

JOURNAL OF MOLECULAR STRUCTURE

Elsevier

Año: 2008 vol. 892 p. 216 - 219

0022-2860

The crystal structure of the title compound, a promising ligand for chelatoterapies in the treatment of Alzheimer’s disease, has been determined by single crystal X-ray diffractometry. It crystallized in the monoclinic space group C2/c with Z = 4. The dimeric 8-quinolinol molecule is sited on a crystallographic two-fold axis passing through the CH2 carbon atom that links the symmetry related molecular halves, giving rise to a two-bladed propeller-like conformation. The 1H- and 13C-NMR- as well as the FTIR and Raman spectra of the compound were also recorded and are briefly discussed. Some comparisons with spectra of related species are made.