Potential antitumoral properties of a new copper complex with Santonic acid

P. A. M. WILLIAMS; J. ZINCZUK; D. A. BARRIO; O. E. PIRO; O. R. NASCIMENTO; S. B. ETCHEVERRY

BIOORGANIC & MEDICINAL CHEMISTRY.

Elsevier

Año: 2008 vol. 16 p. 4313 - 4322

0968-0896

A new copper(II) complex of Santonic acid [Cu2(sant)4(H2O)2].2½ H2O (diaquotetrakissantonatedicopper(II)) has been prepared. Electronic, vibrational and EPR spectral studies have been carried out. X-band EPR signals could not be observed for polycrystalline samples at liquid helium temperature, consistent with two antiferrromagnetically coupled copper centers in the solid state. EPR spectral studies in ethanol solvent at 4.3K show well defined hyperfine signals due to decomposition of the dimer into monomers. The crystal structure of the complex, has been determined by X-ray diffraction methods. The dinuclear Cu(II) complex crystallizes in the tetragonal P43212 space group, with a=b=14.498(3), c=64.07(1) Å, and Z=8 molecules per unit cell. The metals complete their coordination with two water molecules at opposite axial positions. The biological activity studies of the complex, the ligand and the metal ion have been performed on two murine osteoblastic cell lines (one normal and the other tumoral) and on two human colon adenocarcinoma cell lines. Proliferative and morphological assays indicate that the complex displays interesting potential antitumoral actions since it has been more deleterious for the tumoral cell lines than for the non-transformed cells.