IFLP   13074
INSTITUTO DE FISICA LA PLATA
Unidad Ejecutora - UE
artículos
Título:
Glutathione Complexed Iron- Sulfur Centres. Reaction Intermediates and Evidence for a Template Effect Promoting Assembly and Stability
Autor/es:
WENBIN QI; JINGWEI LI; CECILIA Y. CHAIN; GUSTAVO A. PASQUEVICH; ALBERTO F. PASQUEVICH; JAMES COWAN
Revista:
CHEMICAL COMMUNICATIONS
Editorial:
ROYAL SOC CHEMISTRY
Referencias:
Lugar: CAMBRIDGE; Año: 2013 vol. 49 p. 6313 - 6315
ISSN:
1359-7345
Resumen:
Assembly and stabilization of a glutathione-complexed [2Fe?2S] cluster is promoted by aggregation of glutathione. The cluster core selects the tetramer species from a collection of equilibrating solution aggregate species, and in turn the core is stabilized toward hydrolytic degradation. Studies of glutathione derivatives, in combination with mass spectrometric and Mössbauer investigations provide insight on reaction intermediates during formation of [2Fe?2S](GS)42−.