Multitherapy magnetic theranostic: Synthesis, characterization and in vitro evaluation of their performance

MUÑOZ MEDINA, GUILLERMO A.; MONTIEL SCHNEIDER, MARÍA GABRIELA; FERNÁNDEZ VAN RAAP, MARCELA B.; FAVATELA , MARIA FLORENCIA ; LASSALLE, VERÓNICA LETICIA

COLLOIDS AND SURFACES B-BIOINTERFACES

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2021 vol. 198

0927-7765

It is well known that iron oxide magnetic nanoparticles (IOMNs) have many potential utilities in biomedicine due to their unique physicochemical properties. With the aim to obtain multifunctional nanoparticles with potential uses for therapy and diagnosis (nanotheranostics), IOMNs were synthesized by hydrothermal synthesis assisted by mannose. Two synthetic pathways were evaluated in order to obtain MNPs with suitable properties for biomedical applications. Theformulation Mag@Man/H1 presented the best characteristics in terms of size and stability. Mag@Man/H1 was evaluated as: a) drug carrier, b) antioxidant activity, c) magnetic hyperthermia, d) contrast agent for MRI. To evaluate the point a), morin, a natural flavonoid with several pharmaceutical activities, was loaded on the nanoparticles. A high percentage of drug loading was achieved. In point b) the activity of the carrier and the carrier with morin were studied.It was determined that the carrier itself possess a high activity which was greater in morin loaded nanoparticles. Point c) magnetocalorimetric evaluation were carried out at several field conditions. A specific absorption rate value of 121.4 W/gFe was achieved at 52.4 kA/m and 260 kHz and 8.8 W/gFe at 4 kA/m and 100 kHz. Regarding contrast capacity (point d), the r1 value found was small compare to gadolinium contrast agent but close to some contrast agent based on manganese. Although the r2 found was quite smaller than other iron oxides, the effect achieved was strong enough to produce negative contrast. From these studies, it was concluded that Mag@Man/H1 could act as a multifunctional nanoplatform for oncological diseases treatments.