Adesmia boronioides and Solidago chilensis, two novels herbal infusions with toxic effects against colon cancer derived cells.

ASSEF, Y.; GONZÁLEZ, S.; GASTALDI, B.; MARINO, G.

Mar del Plata

Congreso; LXIV Reunión de la Sociedad Argentina de Investigación Clínica; 2018

SAIC

The development and progression of colon cancer is strongly influenced by diet substances that enter in the digestive tract. Herbalinfusions from medicinal plants usually contains phytochemicalsthat can restrain the development and progression of colon cancerin various ways. Flavonoids, an important group of these phytochemicals, report a recognized anti-inflammatory, antioxidant andsignal-regulating properties. Adesmia boronioides and Solidagochilensis are two native medicinal plants that contain flavonoids andhave reported promising antiproliferative activity against T-84 cells.Our aim was to study the toxic effects of herbal infusions obtainedfrom A. boronioides and S. chilensis on Caco-2 and HT-29 cells asmodels of colon cancer.We observed by MTT assay (after 72 h) that the percentage ofviable cells decreased with the increase in the concentration offreeze-dried infusions of both plant species (0 to 50 mg/ml) (p