The Cardiac hypertrophy of the obese agouti mice is not due to hypertension: role of the cardiac TRH system

PERES DIAZ, LS; SCHUMAN, ML; TOBLLI, J; GARCÍA, SI; AISICOVICH, M; LANDA, MS

Orlando

Congreso; Council on Hypertesion; 2016

Council on Hypertension and Council on kidney in cardiovascular disease.

Cardiac TRH (cTRH) is overexpressed in SHR left ventricle. Specific TRH-iRNA treatment induced downregulation of LV-TRH production, preventing cardiac hypertrophy and fibrosis demonstrating that TRH is involved in hypertrophy associated with hypertrophic and fibrotic processes. We confirmed TRH hypertrophy and fibrotic effects in myocytes and fibroblasts. We showed that cTRH participates in the AII-induced hypertrophy mice model. On the other hand, we described the TRH-leptin interaction in the nervous system where leptin induces TRH gene suggesting that this interaction could function also in the heart. Hyperleptinemic obese models present hypertension and hypertrophy, primarily attributable to high pressure. In contrast, we hypothetized that in obese agouti mice (AG) cardiac alterations could be provoked by high leptin levels which could interact with leptin receptors thereby inducing a cTRH increase. Indeed, in AG obese adult males n=10 we confirmed obese phenotype through the increase (p