Metabolic Stressors Associated with Progressive Nonalcoholic Fatty liver Disease and Liver Transcriptional Activity of Alanine and Aspartate Aminotransferases.

SILVIA SOOKOIAN; GUSTAVO O CASTAñO; TOMAS FERNANDEZ GIANOTTI; ROMINA SCIAN; CARLOS J. PIROLA

Boston, MA

Congreso; The 65th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2014; 2014

American Association for the Study of Liver Diseases

Ballooning degeneration is not only a key feature required for the diagnosis of NASH but is associated with progressive NAFLD. We sought to characterize clinical and metabolic predictors associated with hepatocellular ballooning in 256 NAFLD patients at different stages of disease severity. Exploration of liver gene expression of glutamic-pyruvate (GPT1) and glutamic-oxaloacetic (cytoplasmic GOT1 and mitochondrial GOT2) aminotransferases was included to understand their correlation with liver injury. Among explored metabolic stressors, plasma glucose level was significantly associated not only with ballooning but disease progression. Patients without ballooning (101.8±23), absence of lobular inflammation (95±17) and fibrosis scores 0-1 (103±31) had significantly lower glucose levels (mg/dl) than patients with ballooning score 1-2 (122±43, p