Direct action of intestinal microorganisms in colorectal cancer cell line

PALMA AG; DE PAULIS A; NOWICKI S; COSTAS MA; BERNACCHIA JL; ROSA FD; LLEYDA M; RUBIO MF; LIRA MC; LAUDANO O; VAZQUEZ LEVIN M

Mar del Plata

Congreso; Reunión Conjunta SAIC. SAI. SAFIS; 2022

Sociedad Argentina de Investigacion clinica

Numerous evidences demonstrate the importance of the microbiome mainly due to its immunological action, in the development of multiple diseases, such as colorectal cancer (CRC). In agreement with previous works, bacteria such as Escherichia coli (E.coli) and Bacteroides fragilis, among others, have high prevalence in CRC patients compared to the normal population.In this work we investigate the possible pathways and signaling that may contribute to CRC development that could be affected by direct action of bacteria over colorectal cancer cells, in the absence of additional signals from the immune system. Therefore, we first determined the total amount of genes that were up or down regulated (log FC >1 or 4, thus, strongly involved in CRC.We conclude, there are signals and pathways independent of the immune system that could be induced directly by bacteria in the epithelial colorectal cells, contributing to CRC.