GONADECTOMY INFLUENCE BLOOD PRESSURE THROUGH KALLIKREIN KININ SYSTEM

AZURMENDI, PABLO J.; ODDO, ELISABET M.; OBIKA, LEONARD F.; CORBERA, NATALIA L.; MARTIN, RODOLFO S.; IBARRA, FERNANDO R.; ARRIZURIETA, ELVIRA E.

KIDNEY AND BLOOD PRESSURE RESEARCH

Karger

Año: 2009 vol. 32 p. 342 - 348

1420-4096

<!-- /* Font Definitions */ @font-face {font-family:TT10B4Fo00; panose-1:0 0 0 0 0 0 0 0 0 0; mso-font-charset:0; mso-generic-font-family:auto; mso-font-format:other; mso-font-pitch:auto; mso-font-signature:3 0 0 0 1 0;} @font-face {font-family:TT10B4Do00; panose-1:0 0 0 0 0 0 0 0 0 0; mso-font-charset:0; mso-generic-font-family:auto; mso-font-format:other; mso-font-pitch:auto; mso-font-signature:3 0 0 0 1 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0pt; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;} @page Section1 {size:612.0pt 792.0pt; margin:70.85pt 85.05pt 70.85pt 85.05pt; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> GONADECTOMY INFLUENCE BLOOD PRESSURE THROUGH KALLIKREIN KININ SYSTEM. Pablo J. Azurmendi, Elisabet M. Oddo, Leonard F. Obika, Natalia L. Corbera, Rodolfo S. Martín, Fernando R. Ibarra and Elvira E. Arrizurieta. Kallikrein Kinin System (KKS) appears to be involved in blood pressure regulation. We showed that ovariectomy (oVx) stimulates urinary kallikrein activity (UKa). So, we test whether gonadectomy (Gx) would affect blood pressure through an increase in KKS activity and which mechanism/s were involved. We studied adult Wistar rats of either sex, with and without Gx. At baseline all groups were normotensive although the oVx mean arterial pressure (MAP) was lower than female MAP (p<0.05). KKS blockade by aprotinin increased MAP (p<0.05), exclusively in the oVx group. The probably mechanism/s involved in KKS regulation (synthesis, renal content and UKa) were also studied. Previous Gx, kallikrein content (RK, nkat/g kwt) and UKa (nkat/g kwt/day) were higher in female than in male rats: 12±1.1 vs 6±0.7 and 40±6.8 vs 26±3.4, respectively. After Gx, RK increased significantly in both, orquidectomized (oRx) and oVx rats and, UKa showed a similar tendency (NS). Kallikrein synthesis (KLK) did not show gender difference in non-Gx rats but, an increase after oVx was observed. KKS was found to be involved in blood pressure regulation in oVx animals. oVx may trigger the increase in KLK, RK and UKa to act upon blood pressure.