Angiotensin II type 1 receptor blockade in early cirrhosis.

CASTANO GO,; SOOKOIAN SC.

JOURNAL OF HEPATOLOGY

Elsevier

Lugar: England; Año: 2007 vol. 47 p. 426 - 427

0168-8278

AT1R blockers have been used in the treatment of portal hypertension with diverse results. Losartan at doses of 25 mg per day induced a decrease in HVPG equal or greater than 20% in more than 40% of the patients in different studies without serious clinical adverse effects. Nevertheless, higher doses of losartan did not achieve a good hemodynamic response but produced a decrease in arterial pressure and glomerular filtration rate in patients with moderate liver disease . Irbesartan at doses of 150 and 300 mg showed a variable hemodynamic response, but induced hypotension and impaired renal function in patients with Child B or C cirrhosis .