OVARIECTOMY CAUSES OVEREXPRESSION OF RENAL NA+, K+-ATPASE AND SODIUM SENSITIVE HYPERTENSION IN ADULT WISTAR RATS

LUIS A DI CIANO; AZURMENDI P; TOLEDO, JORGE; E ODDO; ZOTTA, ELSA; OCHOA, FEDERICO; ARRIZURIETA, ELVIRA E; IBARRA, FERNANDO R

CLINICAL AND EXPERIMENTAL HYPERTENSION

TAYLOR & FRANCIS INC

Lugar: Londres; Año: 2012

1064-1963

We investigated the effect of ovariectomy on renal and systemic hemodynamic, electrolyte excretion and total and dephosphorylated  Na+, K+-ATPase á 1 subunit (t-d-NKA) in normotensive Wistar rats under a normal (NS, 0.24%) or high sodium (HS, 1%) intake vs  intact female (IF). On NS t-d-NKA was higher in oVx rats and overexpressed in the thick ascending limbs (p<0.01 vs IF) and renal plasma flow was increased. Upon HS, oVx rats maintained a greater dephosphorylated NKA, excreted less sodium and developed arterial hypertension (134±4 vs IF 112±5 mmHg, p<0.05). Sodium load caused salt sensitive hypertension in oVx Wistar rats.