Diencephalic Thyrotropin-Releasing Hormone(trh) May Participate un letpin-Mediated Control Of arterial Blood Pressure(Abp) Exerted By Protein Tyrosine Phosphatase 1b

MARÍA S.LANDA; SILVIA I. GARCÍA; CARLOS J. PIROLA

CIRCULATION

LIPPINCOTT WILLIAMS & WILKINS

Año: 2010 vol. 21 p. 419 - 420

0009-7322

Recently, Belin de Chantemele et al1 reported that protein tyrosinephosphatase 1B may be a major player in the leptin-mediated controlof arterial blood pressure (ABP) in mice. We invite the authors toconsider that the hypothalamic thyrotropin-releasing hormone(TRH) system may be involved in this pathway. Leptin effectsinclude increases in sympathetic activity and inhibition of thestarvation-induced suppression of thyroid hormones by upregulatingpreproTRH gene expression. Furthermore, we showed that intracerebroventricularleptin injections induce a pressor effect that isavoided by preproTRH antisense oligonucleotide pretreatment.2 Inaddition, we showed that diencephalic TRH levels were correlatedwith ABP and leptin levels in 2 genetic models of obesity, thehyperleptinemic and moderately hypertensive agouti yellow mouseand the Ob/Ob mouse, which lacks leptin and is hypotensive.