Lipase-Cstalyzed Synthesis and Spectroscopic Characterization of a Linear Polyamide

LEANDRO MONSALVE; M. KANIZ FATEMA; HIROSHI NONAMI; ALICIA BALDESSARI; ERRA BALSELLS, ROSA

POLYMER

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2010 vol. 51 p. 2998 - 3005

0032-3861

Abstract: A linear polyamidoamine was obtained from ethyl acrylate and N-methyl-1,3-diaminopropane in a polymerization process, catalyzed by the Candida antarctica lipase. Depending on the reaction conditions such as substrates concentration, solvent and enzyme:substrate ratio, the enzyme catalyzes the polymerization reaction or Michael adducts formation. The polymeric material, characterized by FTIR, 1H and 13C NMR and UV-MALDI-TOF-MS, shows low molecular weight and high monodispersity. The activity showed by Candida antarctica lipase in the polymerization reaction is highly selective and allows to obtain a product with potential biomedical applications in mild condition reactions and low environmental impact. Keywords: Lipase-catalyzed. Michael addition. Polyamidoamine.