ELECTRON-CATALYZED RADICAL PERFLUOROALKYLATION OF ORGANIC SULFIDES. THE SERENDIPITOUS USE OF TMEDA/I2 COMPLEX AS RADICAL INITIATOR

MARÍA LAURA UHRIG; B. CAMPS; ALBERTO POSTIGO; ALEJANDRO EZEQUIEL CRISTÓFALO; D. E. YERLEN; MARÍA EMILIA CANO; S. BARATA-VALLEJO; MARÍA LAURA UHRIG; B. CAMPS; ALBERTO POSTIGO; ALEJANDRO EZEQUIEL CRISTÓFALO; D. E. YERLEN; MARÍA EMILIA CANO; S. BARATA-VALLEJO

Catalysis Science and Techonology

ROYAL SOC CHEMISTRY

Año: 2017 vol. 7 p. 2274 - 2282

2044-4761

Radical initiation for the perfluoroalkylation reaction of sulfides has been performed using the complex [(TMEDA) I.I3] and visible light. This methodology bypasses the use of metal(organo)catalysts where the complex [(TMEDA) I.I3] acts as a good electron donor / reductant radical initiating agent. Biologically-relevant sulfides are easily substituted with RF moieties employing a mild and environmentally benign radical strategy starting from readily-available RFI.