Synthesis and antiviral activity of azoles obtained from carbohydrates

BARRADAS, JOSÉ S.; ERREA MARÍA I.; D'ACCORSO, NORMA B.; SEPÚLVEDA CLAUDIA S.; TALARICO LAURA B.; DAMONTE ELSA B.

CARBOHYDRATE RESEARCH

Elsevier

Año: 2008 vol. 343 p. 2468 - 2472

0008-6215

Herein we describe the synthesis of 1,2,4-triazolyl-3-thione;1,3,4-oxadiazole, and imidazo[2,1-b]thiazole derivatives from carbohydrates. The antiviral activity of these compounds was tested against Dengue and Junin virus (the etiological agent of Argentine hemorrhagic fever). The 3-(p-bromobenzoyl)-5-(1,2-O-isopropylidene- 3-O-methyl-a-D-xylofuranos-5-ulos-5-yl)imidazo[2,1-b]thiazole was able to inhibit the replication of both viruses in Vero cells at concentrations significantly lower than the CC50. _ 2008 Published by Elsevier Ltd.