VarQ: an automatic tool for the structural analysis of nsSNPs

JAVIER DELGADO; LUIS SERRANO PUBUL ; LEANDRO G. RADUSKY; MARCELO A. MARTÍ; CHRISTINA KIEL; ADRIAN TURJANSKI

Orlando

Congreso; Intelligent Systems for Molecular Biology; 2016

International Society for Computational Biology

Predicting the detailed effects of variants on the structure and function of a protein is a critical problem to be solved in drug discovery and personalized medicine. Thesevariants can influence drug selection and provoke a variety of effects on the protein behavior A considerable portion of variants effects will result in subtle phenotypiceffects that are challenging to predict. VarQ was developed with the aim of giving to the user a full description of the properties of each variation, extracting knownvariants from reference databases and allowing the user to specify a set novel variations to be analyzed.